Using featured films and TV series as pedagogical tools in medical education has recently surged in popularity. This paper presents a systematic review evaluating their pedagogical applications and analyzing expertise in this field. A total of 17 papers, spanning from 1983 to 2023, were comprehensively analyzed. Results were categorized by original journal, themes, population characteristics, target groups, specific films/series used, instructional methods, and outcomes. Diverse topics emerged, including medical professionalism, bioethics, and critical thinking. 2871 medical students participated in these experiences, mainly from the first- or second year. Most experiences relied solely on films. Articles highlighted the importance of debates around audiovisual materials. The review found featured films and TV series to be valuable supplements to traditional medical education. They enrich students’ learning experiences, deepen engagement with complex subjects, and foster critical skills development, offering an innovative teaching approach.