Use of Rifampicin as a Cytochrome Inducer in Acute Tacrolimus Poisoning

Uso de rifampicina para el tratamiento de la intoxicación aguda por tacrolimus

Tacrolimus is an essential immunosuppressive drug in lung transplantation. It is metabolized by cytochrome P450, which can cause interactions with many drugs. We present a case of acute tacrolimus poisoning in a lung transplant patient following administration of nirmaltrevir/ritonavir, as well as treatment with rifampicin, acytochrome inducer, which allowed blood levels of tacrolimus to be reduced to appropriate values.

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