Introduction Speech and language disturbances are very frequent in progressive supranuclear palsy (PSP). Therefore, they are part of the diagnostic criteria set forth by the International Parkinson and Movement Disorder Society (MDS) for the disease […]
Introduction Parkinson's disease (PD), a prevalent neurodegenerative disorder characterized by motor dysfunction, presents a significant therapeutic challenge due to the lack of disease-modifying treatments. Emerging evidence suggests a crucial role of the gut microbiota in […]
Introduction Differences in the trajectory of non-motor symptoms (NMS) between male and female Parkinson's disease (PD) patients over the course of the disease are not well-understood. Methods PD patients were rated with Non-Motor Symptom Scale […]
Background Systematic reviews (SR) of high methodological quality can provide the best evidence for clinical practice. However, the methodological quality of SRs on Parkinson's disease treatments has not been evaluated comprehensively. The study aims to […]
Introduction Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Although the precise pathogenesis of PD remains unclear, several studies demonstrate that oxidative stress, inflammation, low levels of antioxidants, and the presence of […]
Background Different types of therapies were proven effective for the medical management of motor and non-motor symptoms in Parkinson’s disease (PD). We aimed to gain consensus on the dopamine agonist (DA) therapy use in different […]
Background Mortality in Parkinson’s disease is increasing worldwide, but Spanish data need further study. Objective To analyse the mortality trends of Parkinson’s disease in Spain between 1981 and 2020. Methods This observational retrospective study assessed […]
Parkinson’s disease (PD) accounts for a significant burden on modern society, with an increasingly rapid growth in cases. Variants of several genes have been linked to the risk of developing the disease (e.g., the GBA […]
The genes associated with autosomal recessive Parkinson’s disease (PD) include the PRKN, PINK1, and DJ-1 genes. Homozygous and compound heterozygous carriers of pathogenic variants of these genes tend to display typical characteristics of PD at […]
Background and objective Parkinson’s disease (PD) is the one of the most common neurodegenerative diseases. Many investigators have confirmed the possibility of using circulating miRNAs to diagnose PD. However, the results were inconsistent. Therefore, the […]