Objective
The presence of a new epidemiological focus of Familial Amyloidotic Polyneuropathy (FAP) is reported.
Methods
The demographic, clinical and genetic characteristics of the study are analyzed.
Results
The prevalence in this new focus is higher than in the rest of the national foci but lower than in Portugal. All patients are carriers of c.148G>A (Val30Met) mutation.
Conclusions
The hypothesis of the Portuguese origin of the Zamoran focus is developed both from a genetic and historical point of view.