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Exonic variants of the P2RX7 gene in familial multiple sclerosis
Introduction Several studies have analysed the presence of P2RX7 variants in patients with MS, reporting diverging results. Methods Our study analyses P2RX7 variants detected through whole-exome sequencing (WES). Results We analysed P2RX7, P2RX4, and CAMKK2 […]
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[Translated article] Characteristics, Management, and Prognostic Implications of Adverse Effects of Immune Checkpoint Inhibitors: A Systematic Review
Immune checkpoint inhibitors (ICIs) have significantly advanced the treatment of cancer. They are not, however, free of adverse effects. These effects are called immune-related adverse events (irAEs) and often involve the skin. Most of the […]
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[Translated article] Immunotherapy and Targeted Therapy in Patients With Advanced Melanoma and the V600 BRAF Mutation: Which One First?
Systemic treatment with immunotherapy or targeted therapy can significantly improve survival in patients with advanced (metastatic or high-risk) melanoma. Fifty percent of patients with melanoma have a BRAF mutation. Decisions on optimal sequencing of systemic […]