
Although comedones are a prevalent entity in multiple skin diseases, their perianal location as a cluster is a rare finding. We describe 5 patients with grouped perianal comedones who developed the lesions in adulthood and were treatment-naïve in the perianal area. Four of them had had inflammatory lesions in armpits and groins. In 2, the anatomopathological examination revealed the presence of follicular infundibulum dilatation, cystification, and fibrotic and inflammatory changes in the underlying dermis—findings consistent with hidradenitis suppurativa—which is why we wonder whether grouped perianal comedones are a mild form of hidradenitis suppurativa or an isolated entity.